29. December 2007 by admin.

Genomic DNA is located in the cell nucleus of eukaryotes, as well as small amounts in mitochondria and chloroplasts. In prokaryotes, the DNA is held within an irregularly shaped body in the cytoplasm called the nucleoid.[63] The genetic information in a genome is held within genes. A gene is a unit of heredity and is a region of DNA that influences a particular characteristic in an organism. Genes contain an open reading frame that can be transcribed, as well as regulatory sequences such as promoters and enhancers, which control the expression of the open reading frame.

In many species, only a small fraction of the total sequence of the genome encodes protein. For example, only about 1.5% of the human genome consists of protein-coding exons, with over 50% of human DNA consisting of non-coding repetitive sequences.[64] The reasons for the presence of so much non-coding DNA in eukaryotic genomes and the extraordinary differences in genome size, or C-value, among species represent a long-standing puzzle known as the “C-value enigma.”[65] However, DNA sequences that do not code protein may still encode functional non-coding RNA molecules, which are involved in the regulation of gene expression.[66]

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21. December 2007 by admin.

Bupropion (trade names Wellbutrin, Zyban, and others) is an atypical antidepressant that acts as a norepinephrine and dopamine reuptake inhibitor, and nicotinic antagonist. Bupropion belongs to the chemical class of aminoketones and is similar in structure to the stimulant cathinone, to the anorectic diethylpropion, and to phenethylamines in general. Initially researched and marketed as an antidepressant under the brand name Wellbutrin, bupropion was subsequently found to be effective as a smoking cessation aid. In 2006 it was the fourth-most prescribed antidepressant in the United States retail market, with more than 21 million prescriptions. Bupropion lowers seizure threshold and its potential to cause seizures was widely publicized. However, at the recommended dose the risk of seizures is comparable to the one observed for other antidepressants.

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7. December 2007 by admin.

The basic idea behind all string theories is that the constituents of reality are strings of extremely small size (possibly of the order of the Planck length, about 10⁻³⁵ m) which vibrate at specific resonant frequencies.^[13] Thus, any particle should be thought of as a tiny vibrating object, rather than as a point. This object can vibrate in different modes (just as a guitar string can produce different notes), with every mode appearing as a different particle (electron, photon, etc.). Strings can split and combine, which would appear as particles emitting and absorbing other particles, presumably giving rise to the known interactions between particles.

Levels of magnification: Macroscopic level, molecular level, atomic level, subatomic level, string level.

In addition to strings, this theory also includes objects of higher dimensions, such as D-branes and NS-branes. Furthermore, all string theories predict the existence of degrees of freedom which are usually described as extra dimensions. String theory is thought to include some 10, 11, or 26 dimensions, depending on the specific theory and on the point of view.

Interest in string theory is driven largely by the hope that it will prove to be a consistent theory of quantum gravity or even a theory of everything. It can also naturally describe interactions similar to electromagnetism and the other forces of nature. Superstring theories include fermions, the building blocks of matter, and incorporate supersymmetry, a conjectured (but unobserved) symmetry of nature. It is not yet known whether string theory will be able to describe a universe with the precise collection of forces and particles that is observed, nor how much freedom the theory allows to choose those details.

String theory as a whole has not yet made falsifiable predictions that would allow it to be experimentally tested, though various planned observations and experiments could confirm some essential aspects of the theory, such as supersymmetry and extra dimensions. In addition, the full theory is not yet understood. For example, the theory does not yet have a satisfactory definition outside of perturbation theory; the quantum mechanics of branes (higher dimensional objects than strings) is not understood; the behavior of string theory in cosmological settings (time-dependent backgrounds) is still being worked out; finally, the principle by which string theory selects its vacuum state is a hotly contested topic (see string theory landscape).

String theory is thought to be a certain limit of another, more fundamental theory — M-theory — which is only partly defined and is not well understood.^[14]

^{-Much of the information above is courtesy of Wikipedia}

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